E85 IS worth the hassle providing you have a smart tuner that doesnt tune it at E85!!!! Some will tune at 70, some even lower.
Not all tuners are the same either Go to a tuner that is tried and true and experienced in tuning with it and dont waste your time and money going to somebody who isnt - no matter how much they talk themselves up.
You can have a tuner tune your engine on 98 octane and make X amount of power. Then go to another tuner who tunes your car on E85 and gets less power using ethanol.
Yes, it happens.